{"id":1972,"date":"2024-07-03T13:47:59","date_gmt":"2024-07-03T10:47:59","guid":{"rendered":"http:\/\/genart.bhsc.com.tr\/?page_id=1972"},"modified":"2024-07-03T13:48:47","modified_gmt":"2024-07-03T10:48:47","slug":"pgt","status":"publish","type":"page","link":"https:\/\/genart.com.tr\/en\/pgt\/","title":{"rendered":"PGT"},"content":{"rendered":"<section id=\"bt_section69f755d677538\"  class=\"boldSection gutter\" ><div class=\"port\"><div class=\"boldCell\"><div class=\"boldCellInner\"><div class=\"boldRow\" ><div class=\"boldRowInner\"><div class=\"rowItem col-md-12 col-ms-12  btTextLeft\"  ><div class=\"rowItemContent\" ><div class=\"btText\" ><\/p>\n<h6><\/h6>\n<h6><\/h6>\n<h6>PRE\u0130MPLANTASYON GENET\u0130K TANI (PGT)<\/h6>\n<h6 class=\"icerik_text\"><strong>GEN-ART\u2019ta Preimplantasyon Genetik Tan\u0131 (PGT)<\/strong>Gen-Art\u00a0 2002 y\u0131l\u0131ndan bu yana T\u00fcp Bebek, Kad\u0131n Sa\u011fl\u0131\u011f\u0131 ve \u00dcreme Biyoteknolojisi konular\u0131nda hizmet vermekte olup merkezimizde halihaz\u0131rda y\u00fczlerce hastaya PGT uygulamas\u0131 yap\u0131lm\u0131\u015ft\u0131r. Bu hastalar\u0131n embriyolar\u0131nda genetik inceleme yap\u0131lm\u0131\u015f, anne adaylar\u0131na yaln\u0131zca genetik yap\u0131s\u0131 sa\u011fl\u0131kl\u0131 olan embriyolar\u0131n transferi yap\u0131larak anormal gebelik olu\u015fumu \u00f6nlenmi\u015f ve sa\u011fl\u0131kl\u0131 bebek do\u011fumlar\u0131 sa\u011flanm\u0131\u015ft\u0131r.\u00a0Gen-Art\u2019ta gebelik \u00f6ncesi embriyolar\u0131n genetik incelenmesi\u00a0 ile saptanabilen hastal\u0131k say\u0131s\u0131, deneyimli ve konular\u0131nda uzman ekibimizin \u00e7al\u0131\u015fmalar\u0131yla g\u00fcn ge\u00e7tik\u00e7e artmaktad\u0131r.<strong>PGT nedir\u00a0?<\/strong>Preimplantasyon Genetik Tan\u0131, T\u00fcp bebek uygulamas\u0131 s\u0131ras\u0131nda, embriyolar\u0131n genetik testi yap\u0131larak, sadece sa\u011fl\u0131kl\u0131 olanlar\u0131n se\u00e7ilip anneye transfer edilmesi i\u015flemidir.<strong>PGT\u00a0nin Getirileri ?<\/strong><\/h6>\n<h6 class=\"icerik_text\">1- T\u00fcp bebek uygulamas\u0131n\u0131n ba\u015far\u0131 \u015fans\u0131n\u0131 artt\u0131r\u0131r.<br \/>\n2- Klinik gebelik oran\u0131n\u0131 artt\u0131r\u0131r.<br \/>\n3- Gebeli\u011fin d\u00fc\u015f\u00fck ile sonu\u00e7lanma riskini azalt\u0131r.<br \/>\n4- Gebeli\u011fin t\u0131bbi sonland\u0131r\u0131lma gereklili\u011fini azalt\u0131r.<br \/>\n5- \u00c7o\u011ful gebelik oran\u0131n\u0131 azalt\u0131r.<br \/>\n6- Tekrarlayan ba\u015far\u0131s\u0131z IVF denemelerinin getirdi\u011fi mali y\u00fck ve psikolojik bask\u0131y\u0131 azalt\u0131r.<strong>PGT testi nas\u0131l yap\u0131l\u0131yor ?<\/strong>PGT testi yap\u0131lmas\u0131n\u0131 gerektiren bir durumunuz varsa doktorunuz size bu testi \u00f6nerecektir.Sa\u011fl\u0131kl\u0131 embriyolar\u0131n se\u00e7ilmesi, bir dizi i\u015flem gerektirir:Embriyolar\u0131n\u0131za 3 veya 5. g\u00fcn biyopsi i\u015flemi uygulan\u0131r. Bu i\u015flem embriyolar\u0131n\u0131za zarar vermez.Embriyolar\u0131n\u0131za ait genetik test sonu\u00e7lar\u0131 taze denemelerde 4 ya da 5. g\u00fcn, trofektoderm biyopsilerinde ise t\u00fcm embriyolar\u0131n dondurulup daha sonra transfer edilmesi \u015feklinde planlanmaktad\u0131r.Sa\u011fl\u0131kl\u0131 oldu\u011fu saptanan embriyolar anne aday\u0131na transfer edilmek \u00fczere rapor edilir.Sa\u011fl\u0131kl\u0131 olan ve aran\u0131lan hastal\u0131\u011f\u0131 ta\u015f\u0131mayan embriyolar\u0131n transfer edilmeleri, anneyi sa\u011fl\u0131kl\u0131 bir gebeli\u011fe ba\u015flatm\u0131\u015f olur.<strong>Tecr\u00fcbeli ellerde g\u00fcvenli PGT uygulamas\u0131 ile embriyonuza zarar vermiyoruz<\/strong>.Kullan\u0131lan biyopsi teknikleri ve laboratuvar \u00e7al\u0131\u015fanlar\u0131n\u0131n tecr\u00fcbesi \u00a0biyopsi sonras\u0131 embriyo geli\u015fiminde \u00e7ok \u00f6nemli rol oynar. Klinik, embriyoloji ve genetik laboratuvarlar\u0131n\u0131n y\u00fcksek standartlarda olmas\u0131, sonu\u00e7lar\u0131 etkileyen fakt\u00f6rlerin ba\u015f\u0131nda gelmektedir.Preimplantasyon genetik tan\u0131 yapmak i\u00e7in hastaya ait embriyolar\u0131n her birinden h\u00fccre \u00f6rne\u011fi al\u0131nmas\u0131 gereklidir. PGT uygulamas\u0131 s\u0131ras\u0131nda embriyolar\u0131n zarara u\u011frama ihtimali yok denecek kadar d\u00fc\u015f\u00fckt\u00fcr (hasarlanma oran\u0131 %0.3 olarak tespit edilmi\u015ftir).Kullan\u0131lan y\u00f6nteme g\u00f6re de\u011fi\u015fmekle birlikte PGT testinin hatal\u0131 sonu\u00e7 verme ihtimalinin %2 civar\u0131nda oldu\u011fu bilinmektedir.<strong>PGT Kimlere Yap\u0131lmal\u0131d\u0131r?<\/strong><\/h6>\n<h6 class=\"icerik_text\">1.36 ya\u015f ve \u00fczeri ya\u015ftaki anne adaylar\u0131na<br \/>\n2.\u0130ki veya daha \u00e7ok t\u00fcp bebek uygulanmas\u0131na ra\u011fmen gebelik elde edilememi\u015f \u00e7iftlere<br \/>\n3.Tekrarlayan erken gebelik kay\u0131plar\u0131 (d\u00fc\u015f\u00fckleri) olan \u00e7iftlere (translokasyon ta\u015f\u0131y\u0131c\u0131l\u0131\u011f\u0131 d\u0131\u015f\u0131 sebepli)<br \/>\n4.Dengeli translokasyon ta\u015f\u0131y\u0131c\u0131s\u0131 \u00e7iftlere<br \/>\n5.Ailevi Akdeniz anemisi, Orak H\u00fccre Anemisi, Kistik fibrozis, SMA gibi tan\u0131s\u0131 m\u00fcmk\u00fcn olan baz\u0131 tek gen hastal\u0131klar\u0131 y\u00f6n\u00fcnden risk ta\u015f\u0131yan e\u015flere<br \/>\n6.Aile bireyleri ile HLA uyumlu embriyonun se\u00e7ilmesi<br \/>\n7.\u00d6nceki gebeliklerinden genetik hastal\u0131kl\u0131 bir \u00e7ocuk sahibi olan \u00e7iftlere<br \/>\n8.An\u00f6ploidili (kromozom bozuklu\u011fu bulunan) gebelik \u00f6yk\u00fcs\u00fc olan annelere<br \/>\n9.Gonadal mozaism (\u0130ki yada daha \u00e7ok ayn\u0131 anormalli\u011fe sahip do\u011fum \u00fcr\u00fcn\u00fcne ra\u011fmen e\u015flerin genetik test sonu\u00e7lar\u0131n\u0131n normal olmas\u0131) olgular\u0131na<br \/>\n10.TESE olgular\u0131 (\u015fiddetli erkek infertilitesi ile birlikte olan olgular)<br \/>\n11.Poor responder&#8217;lar (hiperstimulasyon protokol\u00fcne yetersiz cevap veren olgular)<br \/>\n12.X kromozomuna ba\u011fl\u0131 ge\u00e7i\u015f g\u00f6steren hastal\u0131klar a\u00e7\u0131s\u0131ndan e\u011fer s\u00f6z konusu hastal\u0131\u011f\u0131n direkt genetik tan\u0131s\u0131 yap\u0131lam\u0131yorsa embriyonel cinsiyet \u00a0tayini.<strong>Tek Gen Hastal\u0131klar\u0131nda PGT<\/strong><\/h6>\n<h6>Tek gen hastal\u0131klar\u0131 DNA&#8217;m\u0131z \u00fczerinde \u015fifrelenmi\u015f &#8220;gen&#8221; dedi\u011fimiz \u00fcnitelerin fonksiyonlar\u0131n\u0131n bozulmas\u0131 sonucu olu\u015fan genetik hastal\u0131klard\u0131r. Bu t\u00fcr genetik hastal\u0131klar\u0131n e\u015flerin akraba olmalar\u0131 durumunda artt\u0131klar\u0131 iyi bilinmektedir.<\/h6>\n<h6 class=\"icerik_text\">Yurdumuzda e\u015f akrabal\u0131klar\u0131n\u0131n y\u00fcksek s\u0131kl\u0131kta olmas\u0131 nedeniyle bu t\u00fcr hastal\u0131klar\u0131n do\u011fum \u00f6ncesi d\u00f6nemde (prenatal tan\u0131) ve hatta embriyo a\u015famas\u0131nda (preimplantasyon tan\u0131) tan\u0131lar\u0131n\u0131n yap\u0131lmas\u0131 \u00e7ok \u00f6nemlidir. Postnatal (do\u011fum sonras\u0131) ya da prenatal (do\u011fum \u00f6ncesi) tan\u0131nabilen tek gen hastal\u0131klar\u0131n\u0131n tamam\u0131n\u0131n preimplantasyon d\u00f6nem tan\u0131lar\u0131n\u0131n da yap\u0131lmas\u0131 m\u00fcmk\u00fcnd\u00fcr.Tek gen hastal\u0131klar\u0131n\u0131n preimplantasyon genetik tan\u0131s\u0131 tek h\u00fccrenin DNA analizine dayan\u0131r. Kistik fibrosis, talasemi, SMA gibi 150\u2019nin \u00fczerinde tek gen hastal\u0131\u011f\u0131 i\u00e7in PGT yapm\u0131\u015f bulunmaktay\u0131z. Panelimizdeki hastal\u0131klar\u0131n yan\u0131 s\u0131ra genetik tan\u0131s\u0131 koyulabilen her hastal\u0131k i\u00e7in merkezimizde PGT dizayn edebilmekteyiz.<\/h6>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1972","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/genart.com.tr\/en\/wp-json\/wp\/v2\/pages\/1972","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genart.com.tr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/genart.com.tr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/genart.com.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/genart.com.tr\/en\/wp-json\/wp\/v2\/comments?post=1972"}],"version-history":[{"count":3,"href":"https:\/\/genart.com.tr\/en\/wp-json\/wp\/v2\/pages\/1972\/revisions"}],"predecessor-version":[{"id":1975,"href":"https:\/\/genart.com.tr\/en\/wp-json\/wp\/v2\/pages\/1972\/revisions\/1975"}],"wp:attachment":[{"href":"https:\/\/genart.com.tr\/en\/wp-json\/wp\/v2\/media?parent=1972"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}