Where Reproductive Medicine Meets Next-Generation Genetics
Led by Prof. Dr. Volkan Baltacı with over 30,000 clinical genetic diagnosis cases since 1993, we integrate laser trophectoderm biopsy with high-depth NGS under one cohesive scientific ecosystem.
Integrated Biopsy-to-Genetics Workflow
Embryo biopsy and genetic analysis are coordinated within the Gen-Art–Mikrogen ecosystem, minimizing external sample transportation and reducing handling steps between biopsy and genetic analysis.
Preimplantation Genetic Modalities
Day 5 laser-assisted trophectoderm biopsy preserving embryo inner cell mass integrity.
PGT-A (Preimplantation Genetic Testing for Aneuploidy)
PGT-A evaluates the chromosomal status of embryos before transfer. A small sample of trophectoderm cells is analyzed to identify embryos classified as euploid, meaning they have the expected number of chromosomes. Using next-generation sequencing (NGS), chromosome copy number is assessed across all 24 chromosomes, helping identify findings consistent with euploidy, aneuploidy, or selected segmental abnormalities. PGT-A may be considered in selected IVF cases following individualized clinical assessment, particularly when maternal age, reproductive history, or previous treatment outcomes make chromosomal information clinically relevant.
PGT-M (Preimplantation Genetic Testing for Monogenic Disorders)
PGT-M is designed for individuals or couples with a known risk of transmitting a specific inherited single-gene disorder to their children. A customized genetic testing strategy is developed according to the identified familial pathogenic variant, enabling embryos created through IVF to be tested before transfer for the specific inherited condition being investigated.
PGT-SR (Preimplantation Genetic Testing for Structural Chromosomal Rearrangements)
PGT-SR is used for individuals or couples who carry a known structural chromosome rearrangement, such as a balanced translocation or inversion. Although carriers may be healthy, these chromosome rearrangements can increase the risk of embryos with an unbalanced chromosome structure, which may be associated with implantation failure, pregnancy loss, or an affected pregnancy. Genetic analysis is used to identify embryos with unbalanced chromosomal findings associated with structural rearrangements such as reciprocal translocations, Robertsonian translocations, and inversions.
From Embryo Development to Genetic Results
IVF & Embryo Development
Following ovarian stimulation and egg retrieval, fertilization is performed using IVF or ICSI according to the patient’s clinical indication. Embryos are cultured in the laboratory until the blastocyst stage.
Trophectoderm Biopsy & Vitrification
At the blastocyst stage, a small number of trophectoderm cells are carefully sampled for genetic analysis. Following biopsy, the embryo is cryopreserved by vitrification while genetic testing is performed.
Genetic Analysis & Review
The biopsy sample is analyzed according to the clinical indication using PGT-A, PGT-M or PGT-SR. The genetic findings are reviewed together with the patient’s reproductive history and relevant clinical information.
Embryo Transfer Planning
Based on the genetic results and individualized clinical assessment, an embryo considered suitable for transfer may be selected. The frozen embryo transfer is then planned according to the patient’s clinical treatment pathway.
Personalized genetic assessment by our multidisciplinary team to help determine the most appropriate testing and reproductive care pathway based on your medical, reproductive and family history.