Our Science & Technological Innovation
Beyond clinical excellence, GEN-ART is an integrated reproductive biotechnology ecosystem, combining advanced fertility care with scientific research, patented innovations, and the development of next-generation technologies in reproductive medicine and genetics.
Research & Publications
International and national peer-reviewed publications by Prof. Dr. Volkan Baltacı and colleagues in reproductive medicine and medical genetics, spanning from 1992 to present.
Piezoelectric Oocyte Activation
Clinical research by Baltacı and colleagues investigated piezoelectric stimulation in selected patients with previous total fertilization failure.
Oocyte maturation abnormalities – A systematic review of the evidence and mechanisms in a rare but difficult to manage fertility phenomena. Hatırnaz Ş, Hatırnaz ES, Ellibeş Kaya A, Hatırnaz K, Soyer Çalışkan C, Sezer Ö, Dokuzeylül Güngor N, Demirel C, Baltacı V, Tan S, Dahan M. Turk J Obstet Gynecol. 2022 Mar 28;19(1):60-80. doi: 10.4274/tjod.galenos.2022.76329.
Can PCNA and LIM15 gene expression levels predict sperm retrieval success in men with non-obstructive azoospermia? Ibis MA, Aydos K, Baltaci V, Aktuna S, Yaman O. Rev Int Androl. 2022 May 12:S1698-031X(22)00039-5. doi: 10.1016/j.androl.2021.04.002.
Early-infantile onset epilepsy and developmental delay caused by bi-allelic GAD1 variants. Neuray C, Maroofian R, Scala M, Sultan T, Pai GS, Mojarrad M, Khashab HE, deHoll L, Yue W, Alsaif HS, Zanetti MN, Bello O, Person R, Eslahi A, Khazaei Z, Feizabadi MH, Efthymiou S; SYNaPS Study Group, El-Bassyouni HT, Soliman DR, Tekes S, Ozer L, Baltaci V, Khan S, Beetz C, Amr KS, Salpietro V, Jamshidi Y, Alkuraya FS, Houlden H. Brain. 2020 Aug 1;143(8):2388-2397. doi: 10.1093/brain/awaa178.
Mandibuloacral Dysplasia and LMNA A529V mutation in Turkish patients with Severe Skeletal Changes and Absent Breast Development. Ozer L, Unsal E, Aktuna S, Baltaci V, Akyiğit F, Ayvaz O, Balci S. Clin Dysmorphol. 2016 Jul;25(3):91-7.
Prenatal Cytogenetic Findings in 13.466 Cases of High-Risk Pregnant Women in One Laboratory. Ozer L, Unsal E, Ayvaz Ö, Şen A, Baltaci V. MN GORM. 2013 19(3): 139-147.
Genetic Aspects of Recurrent Miscarriages. Volkan Baltaci, and Ege Baltaci. JSM Invitro Fertilisation. 2016. 1(1): 2002.
Oogonial Precursor Cell-Derived Autologous Mitochondria Injection to Improve Outcomes in Women With Multiple IVF Failures Due to Low Oocyte Quality: A Clinical Translation. Oktay K, Baltaci V, Sonmezer M, Turan V, Unsal E, Baltaci A, Aktuna S, Moy F. Reprod Sci. 2015 Dec;22(12):1612-7.
Effects of pentoxifylline and platelet activating factor on sperm DNA damage. Unsal E, Turan V, Aktuna S, Hurdag C, Bereketoglu G, Canillioglu Y, Baltacı A, Ozcan S, Karayalcin R, Batırbaygil H, Baltacı V. Eur J Obstet Gynecol Reprod Biol. 2016 Feb;197:125-9.
Proprietary Bioengineering Tools
Mismatch Blocker™ double-witnessing, BioPSafe™ biopsy safety, and specialized cryopreservation devices.
WE DON’T JUST USE TECHNOLOGYWE DEVELOP IT
Unlike clinics that merely purchase commercial equipment, Gen-Art and Mikrogen innovate proprietary medical devices and genetic assays.
Reproductive Genetics
EmbryoSeq and custom high-resolution PGT sequencing workflows engineered in-house for complex single-gene variants.
- Custom PGT-M informative probe design
- Segmental aneuploidy high-depth NGS
- Rapid-turnaround bioinformatics analysis
Embryo Safety Technologies
Proprietary witnessing, specimen tracking, and barcode/RFID verification hardware built to eliminate human error.
- Biopsy-stage witnessing protocols
- Micro-station specimen verification
- Cryptographic identity binding
Embryology Innovation
Next-generation embryo handling and cryo-storage innovations (such as the BioPSafe and Zeus initiatives).
- Controlled LN2 retrieval protocols
- Enhanced vitrification micro-devices
- Automated laboratory surveillance